![]() In contrast, a subsequent study indicates robust proliferation and migration in the human SVZ and RMS 8, 9. An initial report finds few SVZ proliferating cells and rare migrating immature neurons in the RMS of adult humans 7. Some of these SVZ astrocytes can function as neural stem cells in vitro, but their function in vivo remains controversial. ![]() The adult human SVZ, in contrast, contains a hypocellular gap layer separating the ependymal lining from a periventricular ribbon of astrocytes 7. Along the walls of the lateral ventricles, immature neuronal progeny migrate in tangentially-oriented chains that coalesce into a rostral migratory stream (RMS) connecting the SVZ to the OB. The subventricular zone (SVZ) of many adult non-human mammals generates large numbers of new neurons destined for the olfactory bulb (OB) 1– 6.
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